The Colorado won the first leg 1-0, but Once Caldas went ahead in Colombia through a converted spot kick from Jorge Nunez in the third minute.
However moments later, Mauricio Casierra hacked down Oscar in the box and the referee blew for another penalty which D’Alessandro cooly put away inside the 11th minute.
Tinga then gave Inter the lead with a close range finish in the 22nd minute, before Mario Gonzalez equalised for Once three minutes later.
With no further goals in the second half, Internacional progressed in to the group stages of the Libertadores where they will face Juan Aurich (PER), The Strongest (BOL) and last years winners Santos (BRZ) in Group 1.
