Manchester United midfielder Anderson came on as a second-half substitute to make his 150th appearance for the club, while fellow Brazilian Rafael impressed once more at right-back.
Anderson, 24, who has found it difficult to win a place in the Red Devils’ line-up in recent times once more did well when given an opportunity and will no doubt have put pressure on manager Sir Alex Ferguson to hand him a start in upcoming fixtures.
The Brazilian’s range of passing was on display once more and, in a midfield that often lacks energy, the former Grêmio player injected dynamism alongside Michael Carrick.
Rafael was quieter than in previous matches, but made a couple of important interventions in defence to prevent the concession of more than two goals.
Whilst the United centre-backs looked below usual standards, the Brazil international produced another mature display and linked well with Ecuadorian winger Antonio Valencia on the right-flank.
Most pleasing, perhaps, was that the 22-year-old fronted up well to the intense physical challenge presented by Stoke, including a strong showing when defending aerial balls.
Goals from Wayne Rooney (2), Robin van Persie and Danny Welbeck saw the home-side to what was ultimately a comfortable home victory.