Fluminense maintained their title lead after a early scare against Ponte Preta. Goals from Fred and Gum overcame an early Luan strike.
Atlético Mineiro kept up the title chase in second after winning 2-1 at Sport Recife. A Leonardo brace was enough to secure the three points.
In third place, Grêmio were held to a 1-1 draw against Botafogo after Bruno Mendes grabbed an injury time equaliser to rescue a point for the away side.
Goals from Luis Fabiano and Douglas gave São Paulo a comfortable 2-0 victory over Figuirense to stay in the final Copa Libertadores spot.
Miralles struck twice either side of half time to give Santos a 2-0 win over Vasco.
Palmeiras’ relegation woes continued as they lost to Náutico courtesy of a Kieza goal to leave them nine points adrift off safety.
Early goals from Marcelo Cordeiro and Douglas meant that points were shared as Corinthians drew 1-1 with Portuguesa.
Deivid grabbed the winner as Coritiba defeated Bahia to distance themselves from the relegation zone.